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Maria Franzini

Icona sede Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia

Location: VIA SAVI 10, 56126 PISA

Email: maria.franzini@unipi.it

Phone: 050 993311

Maria Franzini

Profile

Position: Professore Associato

Unit: Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia

Scientific-disciplinary sector: Patologia Clinica MEDS-02/B

PERSONAL INFORMATION
Place and date of birth: Pisa, February 23, 1978.
Institutional address: S. Chiara Hospital, Clinical Pathology Laboratory, Building 43, via Roma 67, 56126 Pisa, Italy.

EDUCATION AND TRAINING
2017: Second-level Master’s Degree in “Thrombosis and Hemostasis” with honors, University of Florence.
2014: Specialization in Clinical Pathology with honors, University of Pisa.
2007: PhD (Doctor Europaeus label) in “Cellular Pathology and Pathophysiology,” University of Siena.
2003: Degree in Biological Sciences with honors, University of Pisa.
2001 and 2002: Training periods at Université H. Poincaré - Nancy I (France), "Thiols and Cellular Functions" laboratory.
1997: Scientific High School Diploma, F. Buonarroti High School, Pisa.

PROFESSIONAL EXPERIENCE
2023: Associate Professor in Clinical Pathology (MEDS-02/B), University of Pisa with affiliated duties as Senior Biologist at the University Hospital of Pisa.
2020–2023: Fixed-term Researcher (law 240/2010: art. 24, paragraph 3, letter b) in Clinical Pathology (MEDS-02/B), University of Pisa with affiliated duties as Senior Biologist at the University Hospital of Pisa.
2015–2020: Fixed-term Researcher (law 240/2010: art. 24, paragraph 3, letter a) in Clinical Pathology (MEDS-02/B), University of Pisa with affiliated duties as Senior Biologist at the University Hospital of Pisa.
2007–2011 and 2011–2014: Research collaborator at the Scuola Superiore Sant'Anna, studying cardiovascular biomarkers (BNP, NT-proBNP, cardiac troponin, plasma fractions of the enzyme gamma-glutamyltransferase).

MAIN SCIENTIFIC INTERESTS
- Characterization of circulating fractions of the protein transthyretin and their role in the pathogenesis of cardiac amyloidosis.
- Evaluation of analytical and clinical characteristics of new immunometric methods for automated determination of cardiac markers (BNP, NT-proBNP, cardiac troponin I and T) and free light chains of antibodies.
- Characterization of plasma andbiliary fractions of the enzyme gamma-glutamyltransferase (GGT) as indicators of liver damage, liver function post-transplant, and cardiovascular risk factors.
- Structural and compositional characterization of plasma fractions of GGT.
- Characterization of cell types capable of releasing the GGT enzyme.
- Role of membrane-bound GGT activity in modulating the extracellular microenvironment.
- Role of GGT in the catabolism of nitrosoglutathione.
- Oxidative stress in neurodegenerative diseases.

COLLABORATION WITH NATIONAL AND INTERNATIONAL INSTITUTIONS
- CAMELIA Project (Cardiovascular risks, Metabolic Syndrome, Liver, and Autoimmune Disease): University of Milan; ASL Milan 1; Calabrian Association of Hepatology (Dr. C. Caserta), Reggio Calabria; Istituto Superiore di Sanità, Rome.
- Dr. Alessandro De Grandi, EurAc (Bolzano).
- Boston Children’s Hospital, Harvard Medical School: Prof. Mark Puder – collaboration on the project “GGT Characterization in Parenteral Nutrition-Dependent Children”.
- Framingham Heart Study – National Heart, Lung, and Blood Institute, Boston University (USA): Prof. Ramachandran Vasan.

COLLABORATIONS WITH COMPANIES IN THE IVD SECTOR
In collaboration with bioMérieux Italia S.p.A. (Via di Campigliano 58, Ponte a Ema 50012 Bagno a Ripoli, Florence), the following funded projects were carried out:
2022–2023: "Improvement of the analytical characteristics of clinical tests for integration on a multiparametric Point of Care system."
2020–2021: "Improvement of analytical characteristics of immunological tests by increasing sensitivity and multiparametric testing capability."
2018–2019: "Improvement of analytical characteristics of immunological tests by controlled orientation of capture-phase antibodies and fluorescence detection."
2016–2017: "Conjugation of fluorochromes for high-sensitivity detection in immunochemical analytical systems."

Teaching

Teaching activity

Teaching responsibility for modules/courses

  • Immunologia e tecniche immunologiche (cod. 334FF) per Laurea in Biotecnologie
    Insegnamenti condivisi/mutuati:
    • Immunologia e tecniche immunologiche (cod. 334FF) - Laurea in Scienze biologiche
    • Immunologia e tecniche immunologiche (cod. 334FF) - Laurea in Scienze biologiche
  • Patologia clinica (modulo dell'insegnamento scienze mediche i cod. 300ff) per Laurea Magistrale Ciclo Unico 6 anni in Odontoiatria e protesi dentaria
  • Patologia clinica (cod. 115FF) per Laurea Magistrale in Biologia applicata alla biomedicina

Incarichi di co-docenza in moduli/insegnamenti

  • Analisi Biochimico-cliniche (Cod. 563EE) per Laurea Magistrale in Biologia applicata alla biomedicina
  • Physio-pathology (Cod. 023FE) per Laurea Magistrale in Biotechnologies and applied artificial intelligence for health
Teaching register
Lesson timetable

Student consultation hours

Location: Laboratorio di Patologia Clinica
Ospedale Santa Chiara, Edificio 43, II piano
Studio: corridoio sx, prima porta sx
Laboratorio: corridoio dx, prima porta sx

Time: Previo appuntamento da concordare preferibilmente tramite e-mail

Research

Publications

All publications by Maria Franzini on ARPI, the Research Archive of the University of Pisa

Academic news

Giovanni Federico Gronchi Maria Franzini

The University of Pisa Partners in the BASE Project with Palestinian and Jordanian Universities

The objective is to align the university systems of both countries with European standards

Accedi per modificare i dati
  • Università di Pisa
  • Lungarno Pacinotti, 43
  • P.I. 00286820501 C.F. 80003670504
  • T. +39 050 221 2111
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