Profile
Position: Professore Associato
Unit: Dipartimento di Medicina Clinica e Sperimentale
Scientific-disciplinary sector: Medicina Interna MEDS-05/A
Prof. Stefano Masi is an Associate Professor of Internal Medicine at the Department of Clinical and Experimental Medicine, University of Pisa, with over 15 years of international experience in cardiovascular and metabolic research. He also serves as Consultant in Internal Medicine at the Pisa University Hospital and works at the Regional Referral Center for the Diagnosis and Treatment of Arterial Hypertension, within the Division of Internal Medicine I.
Prof. Masi completed his postgraduate training in Internal Medicine with honors at the University of Pisa. He then moved to the United Kingdom, where he earned a PhD in Cardiovascular Sciences at University College London. He subsequently received a Career Development Fellowship from the NIHR (National Institute for Health and Care Research) at the same institution, as well as a Clinical Lectureship in Geriatrics and Internal Medicine at King’s College London.
Currently, Prof. Masi coordinates a laboratory dedicated to the characterization of macrovascular damage in patients with cardiometabolic and liver diseases at the Department of Clinical and Experimental Medicine, University of Pisa. He supervises two PhD students, two laboratory technicians, one postdoctoral fellow, and four residents in Internal Medicine. He has served as a clinical tutor in the “MBBS Cardiometabolic Patient Pathway” module at University College London’s medical degree program, and he currently teaches Internal Medicine in two degree courses at the University of Pisa. He is also a member of the board of two PhD programs (in Hypertension and Vascular Biology at the University of Padua, and in Translational Medicine at the Scuola Superiore Sant’Anna, Pisa) and teaches in the PhD course “Clinical Trials in Cardiovascular Pharmacotherapy” at the Karolinska Institute, Stockholm, Sweden.
At the University of Pisa, Prof. Masi is a member of the governing board of the Department of Clinical and Experimental Medicine, where he also serve as delegate for internationalization. He previously served as Vice-Director of the Postgraduate School in Internal Medicine. He is also Vice-Chair of the Area 06 Scientific Committee and one of three members of the evaluation panel for medical projects within the Italian National Recovery and Resilience Plan (PNRR).
Prof. Masi’s research explores the impact of traditional and emerging risk factors—including common chronic inflammatory conditions—on cardiovascular risk in both primary and secondary prevention. His work focuses particularly on the mechanisms underlying the transition from hypertension- and diabetes-mediated cardiac damage to heart failure. His translational research spans from basic science to advanced non-invasive ultrasound imaging techniques, used to characterize early cardiovascular damage and its determinants. Furthermore, he leverages large epidemiological databases, including genetic data, to define causal relationships between circulating biomarkers and cardiovascular outcomes, employing artificial intelligence approaches.
He has published more than 170 scientific papers in leading international cardiovascular journals, including The Lancet, Circulation, European Heart Journal, The Lancet Diabetes & Endocrinology, Circulation Research, Cardiovascular Research, Journal of the American College of Cardiology – Cardiovascular Imaging, and European Journal of Heart Failure. He has contributed to consensus documents and practical guidelines for both the Italian Society of Hypertension and the European Society of Hypertension.
Prof. Masi serves as a reviewer for several high-impact journals, is Associate Editor of the European Heart Journal, and a member of the Editorial Board of the Journal of Clinical Medicine. He has been involved in organizing national congresses for the Italian Society of Hypertension and the Italian Society of Internal Medicine, and currently serves as President of the Tuscany-Umbria Section of the Italian Society of Internal Medicin
Prof. Masi completed his postgraduate training in Internal Medicine with honors at the University of Pisa. He then moved to the United Kingdom, where he earned a PhD in Cardiovascular Sciences at University College London. He subsequently received a Career Development Fellowship from the NIHR (National Institute for Health and Care Research) at the same institution, as well as a Clinical Lectureship in Geriatrics and Internal Medicine at King’s College London.
Currently, Prof. Masi coordinates a laboratory dedicated to the characterization of macrovascular damage in patients with cardiometabolic and liver diseases at the Department of Clinical and Experimental Medicine, University of Pisa. He supervises two PhD students, two laboratory technicians, one postdoctoral fellow, and four residents in Internal Medicine. He has served as a clinical tutor in the “MBBS Cardiometabolic Patient Pathway” module at University College London’s medical degree program, and he currently teaches Internal Medicine in two degree courses at the University of Pisa. He is also a member of the board of two PhD programs (in Hypertension and Vascular Biology at the University of Padua, and in Translational Medicine at the Scuola Superiore Sant’Anna, Pisa) and teaches in the PhD course “Clinical Trials in Cardiovascular Pharmacotherapy” at the Karolinska Institute, Stockholm, Sweden.
At the University of Pisa, Prof. Masi is a member of the governing board of the Department of Clinical and Experimental Medicine, where he also serve as delegate for internationalization. He previously served as Vice-Director of the Postgraduate School in Internal Medicine. He is also Vice-Chair of the Area 06 Scientific Committee and one of three members of the evaluation panel for medical projects within the Italian National Recovery and Resilience Plan (PNRR).
Prof. Masi’s research explores the impact of traditional and emerging risk factors—including common chronic inflammatory conditions—on cardiovascular risk in both primary and secondary prevention. His work focuses particularly on the mechanisms underlying the transition from hypertension- and diabetes-mediated cardiac damage to heart failure. His translational research spans from basic science to advanced non-invasive ultrasound imaging techniques, used to characterize early cardiovascular damage and its determinants. Furthermore, he leverages large epidemiological databases, including genetic data, to define causal relationships between circulating biomarkers and cardiovascular outcomes, employing artificial intelligence approaches.
He has published more than 170 scientific papers in leading international cardiovascular journals, including The Lancet, Circulation, European Heart Journal, The Lancet Diabetes & Endocrinology, Circulation Research, Cardiovascular Research, Journal of the American College of Cardiology – Cardiovascular Imaging, and European Journal of Heart Failure. He has contributed to consensus documents and practical guidelines for both the Italian Society of Hypertension and the European Society of Hypertension.
Prof. Masi serves as a reviewer for several high-impact journals, is Associate Editor of the European Heart Journal, and a member of the Editorial Board of the Journal of Clinical Medicine. He has been involved in organizing national congresses for the Italian Society of Hypertension and the Italian Society of Internal Medicine, and currently serves as President of the Tuscany-Umbria Section of the Italian Society of Internal Medicin
Teaching
Teaching activity
Teaching responsibility for modules/courses
- Medicina interna (modulo dell'insegnamento scienze mediche e ostetriche con farmacologia cod. 023ef) per Laurea in Ostetricia (abilitante alla professione sanitaria di ostetrica/o)
- Tirocinio professionalizzante iii anno - medicina interna (modulo dell'insegnamento tirocinio professionalizzante iii anno cod. 303ff) per Laurea Magistrale Ciclo Unico 6 anni in Odontoiatria e protesi dentaria
- Medicina interna (modulo dell'insegnamento scienze mediche i cod. 300ff) per Laurea Magistrale Ciclo Unico 6 anni in Odontoiatria e protesi dentaria
Incarichi di co-docenza in moduli/insegnamenti
- Tirocinio di Clinica Medica e Cure Palliative (Cod. 1761Z) per Laurea Magistrale Ciclo Unico 6 anni in Medicina e chirurgia
- Semeiotica - Corso ACCADEMIA (Modulo dell'insegnamento Semeiotica e Metodologia Clinica Cod. 034FF) per Laurea Magistrale Ciclo Unico 6 anni in Medicina e chirurgia
- Semeiotica - Corso LZ (Modulo dell'insegnamento Semeiotica e Metodologia Clinica Cod. 034FF) per Laurea Magistrale Ciclo Unico 6 anni in Medicina e chirurgia
Student consultation hours
Mode of office hours: Il docente riceve su appuntamento concordato via e-mail o telefonicamente.
Research
Publications
- Transdermal Clonidine for Hypertension: An Underutilized Ally in the Modern Era (Masi, Stefano; Pugliese, Nicola Riccardo; Taddei, Stefano; Ferri, Claudio; Borghi, Claudio - 2026 - 1.1 Articolo in rivista)
- Artificial intelligence-based characterization of multi-organ ultrasound congestion across the heart failure Spectrum (Del Punta, Lavinia; Aru, Giacomo; Sirbu, Alina; De Biase, Nicolò; Taddei, Stefano; Prencipe, Giuseppe; Masi, Stefano; Pugliese, Nicola Riccardo - 2026 - 1.1 Articolo in rivista)
- Triglyceride–glucose index and its derived anthropometric indices: a comparative analysis for mortality prediction in the population cohort of the URRAH study (D'Elia, Lanfranco; Galletti, Ferruccio; Virdis, Agostino; Casiglia, Edoardo; Tikhonoff, Valerie; Angeli, Fabio; Barbagallo, Carlo Maria; Bombelli, Michele; Cianci, Rosario; Ciccarelli, Michele; Cicero, Arrigo F. G.; Cirillo, Massimo; Cirillo, Pietro; Desideri, Giovambattista; Ferri, Claudio; Gesualdo, Loreto; Giannattasio, Cristina; Grassi, Guido; Iaccarino, Guido; Lippa, Luciano; Mallamaci, Francesca; Maloberti, Alessandro; Masi, Stefano; Mazza, Alberto; Mengozzi, Alessandro; Muiesan, Maria Lorenza; Nazzaro, Pietro; Palatini, Paolo; Parati, Gianfranco; Pardini, Noemi; Pontremoli, Roberto; Quarti-Trevano, Fosca; Rattazzi, Marcello; Reboldi, Gianpaolo; Rivasi, Giulia; Russo, Elisa; Salvetti, Massimo; Tocci, Giuliano; Ungar, Andrea; Verdecchia, Paolo; Viazzi, Francesca; Volpe, Massimo; Borghi, Claudio; Borghi, Claudio; Angeli, Fabio; Barbagallo, Carlo Maria; Bombelli, Michele; Casiglia, Edoardo; Cianci, Rosario; Ciccarelli, Michele; Cicero, Arrigo F. G.; Cirillo, Massimo; Cirillo, Pietro; D'Elia, Lanfranco; Dell'Oro, Raffaella; Desideri, Giovambattista; Ferri, Claudio; Galletti, Ferruccio; Gesualdo, Loreto; Giannattasio, Cristina; Grassi, Guido; Iaccarino, Guido; Lippa, Luciano; Mallamaci, Francesca; Maloberti, Alessandro; Masi, Stefano; Masulli, Maria; Mazza, Alberto; Mengozzi, Alessandro; Muiesan, Maria Lorenza; Nazzaro, Pietro; Palatini, Paolo; Parati, Gianfranco; Pontremoli, Roberto; Quarti-Trevano, Fosca; Rattazzi, Marcello; Reboldi, Gianpaolo; Rivasi, Giulia; Russo, Elisa; Salvetti, Massimo; Tikhonoff, Valerie; Tocci, Giuliano; Ungar, Andrea; Verdecchia, Paolo; Viazzi, Francesca; Virdis, Agostino; Volpe, Massimo - 2026 - 1.1 Articolo in rivista)
- National and subnational burden of disease attributable to risk factors in Italy, 1990–2023: a systematic analysis from the Global Burden of Disease Study 2023 (Zamagni, Giulia; Carreras, Giulia; Armocida, Benedetta; Gakidou, Emmanuela; Ashbaugh, Charlie; Alicandro, Gianfranco; Bragazzi, Nicola Luigi; Carletti, Claudia Veronica; Caselli, Luana; Cerrai, Sonia; Concina, Federica; Conti, Sara; Cosma, Claudia; D'Amico, Emanuele; Deandrea, Silvia; Riccio, Marco Del; Ferrara, Pietro; Fornari, Carla; Fortuna, Daniela; Gallus, Silvano; Galluzzo, Lucia; Grosso, Giuseppe; Guarducci, Giovanni; Guicciardi, Stefano; Iavicoli, Ivo; Lachi, Alessio; Leonardi, Matilde; Levi, Miriam; Lugo, Alessandra; Maffia, Pasquale; Masi, Stefano; Maurel, Eleonora; Nieddu, Luciano; Pani, Paola; Passera, Roberto; Pedersini, Paolo; Perico, Norberto; Raggi, Alberto; Remuzzi, Giuseppe; Ronfani, Luca; Sabbatucci, Michela; Traini, Eugenio; Tricò, Domenico; Urso, Daniele; Zanghì, Aurora; Zovi, Andrea; Mansson, Johan; Naghavi, Mohsen; Piccinelli, Cristiano; Monasta, Lorenzo - 2026 - 1.1 Articolo in rivista)
- Heart failure with reduced ejection fraction in Sweden: patient adherence and persistence to quadruple pharmacotherapy prescription (Lindberg, Felix; Uijl, Alicia; Benson, Lina; Valente, Valeria; Coats, Andrew J S; Böhm, Michael; Metra, Marco; Masi, Stefano; Lund, Lars H; Rosano, Giuseppe M C; Savarese, Gianluigi - 2026 - 1.1 Articolo in rivista)
- Managing glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors in clinical practice (Dalpiaz, H.; Masi, S.; Piludu, S.; Agnoletti, D.; Piani, F.; Fiorini, G.; Borghi, C. - 2026 - 1.1 Articolo in rivista)
- The Role of ß-Blockers in the Evolving Treatment Landscape of Resistant Hypertension (Masi, S.; Pathak, A.; Bruno, R. M.; Brouwers, S.; Narkiewicz, K.; Taddei, S.; Tsioufis, K.; Kreutz, R. - 2026 - 1.1 Articolo in rivista)
- Emerging evidence from combination therapy reinforces the role of ß-blockers in resistant hypertension (Masi, Stefano; Borghi, Claudio - 2026 - 1.1 Articolo in rivista)
- Gut Microbiota Manipulation by Probiotic Lacticaseibacillus paracasei DG I1572 as New Therapeutical Strategy to Counteract Vascular Inflammaging (D'Antongiovanni, V.; Salvo, C. D.; Valdiserra, G.; Fornai, M.; Cappelli, F.; Mengozzi, A.; Virdis, A.; Masi, S.; Duranti, E.; Benvenuti, L.; Fiore, W.; De Vitis, V.; Antonioli, L. - 2026 - 1.1 Articolo in rivista)
- Hemodynamic and Metabolic-Inflammatory Phenotyping Across the Cardiac Index Spectrum in Moderate and Severe Tricuspid Regurgitation: Prognostic Implications (Mazzola, Matteo; De Biase, Nicolò; Giannini, Cristina; Sticchi, Alessandro; Del Punta, Lavinia; Gargani, Luna; Mengozzi, Alessandro; Virdis, Agostino; Armenia, Silvia; Cappelli, Federica; Duranti, Emiliano; Taddei, Stefano; Hahn, Rebecca; Messika-Zeitoun, David; Masi, Stefano; De Carlo, Marco; Pugliese, Nicola Riccardo - 2026 - 1.1 Articolo in rivista)
- N-Acylethanolamine Acid Amidase Inhibition Reduces SARS-CoV-2 Infection in Human Precision Cut-Lung Slices and Downregulates NF-KBB Signalling (La Rocca, Veronica; Filipponi, Carolina; Diesendorf, Viktoria; De Carli, Alessandro; Sciandrone, Giulia; Nottoli, Silvia; Plicanti, Erika; Fonnesu, Rossella; Iacono, Elena; Mengozzi, Alessandro; Masi, Stefano; Lenzi, Paola; Fornai, Francesco; Sewald, Katherina; Obernolte, Helena; Angelini, Roberto; Bodem, Jochen; Freer, Giulia; Pistello, Mauro; Lai, Michele - 2026 - 1.1 Articolo in rivista)
- Under Pressure (Masi, Stefano; Dalpiaz, Hermann; Savarese, Gianluigi - 2025 - 1.1 Articolo in rivista)
- Hypertensive heart disease in older patients: considerations for clinical practice (Camafort, Miguel; Kasiakogias, Alexandros; Agabiti-Rosei, Enrico; Masi, Stefano; Iliakis, Panagiotis; Benetos, Athanase; Jeong, Jin-Ok; Lee, Hae-Young; Muiesan, Maria Lorenza; Sudano, Isabella; Tsioufis, Costas - 2025 - 1.1 Articolo in rivista)
- Expert Consensus on the Primary Aldosteronism Severity Classification and its strategic application in indicating adrenal venous sampling (Murakami, Masanori; Naruse, Mitsuhide; Kobayashi, Hiroki; Parasiliti-Caprino, Mirko; Bioletto, Fabio; Brüdgam, Denise; Stüfchen, Isabel; Reincke, Martin; St-Jean, Matthieu; Kraljevic, Ivana; Kastelan, Darko; Nevalainen, Pasi I; Araujo-Castro, Marta; Sukor, Norlela; Nijhoff, Michiel F; Matrozova, Joanna; Ragnarsson, Oskar; Shafigullina, Zulfiya; Matikainen, Niina; Markou, Athina; Piaditis, George; Izawa, Shoichiro; Katabami, Takuyuki; Ichijo, Takamasa; Tanabe, Akiyo; Tsuiki, Mika; Kakutani, Miki; Wada, Norio; Masuda, Seizaburo; Bacca, Alessandra Violet; Beuschlein, Felix; Maiolino, Giuseppe; Falhammar, Henrik; Grytaas, Marianne A; Løvås, Kristian; Almeida, Madson Q; Furnica, Raluca Maria; Puar, Troy; Kmiec, Piotr; Masi, Stefano; Bourdeau, Isabelle; Amar, Laurence; Dennedy, Michael Conall; Fallo, Francesco; Deinum, Jaap; O'Toole, Sam; Yamada, Tetsuya; Quinkler, Marcus; Lacroix, André; Kocjan, Tomaz - 2025 - 1.1 Articolo in rivista)
- Global, regional, and national trends in routine childhood vaccination coverage from 1980 to 2023 with forecasts to 2030: a systematic analysis for the Global Burden of Disease Study 2023 (Haeuser, Emily; Byrne, Sam; Nguyen, Jason; Raggi, Catalina; Mclaughlin, Susan A; Bisignano, Catherine; Harris, Ashley A; Smith, Amanda E; Lindstedt, Paulina A; Smith, Georgia; Herold, Samuel James; Nesbit, Olivia D; Noyes, Taylor; Shalev, Noga; Olana, Latera Tesfaye; Aalipour, Mohammad Amin; Aalruz, Hasan; Abbasifard, Mitra; Abbaspour, Faezeh; Abbastabar, Hedayat; Abd Elhafeez, Samar; Abdallah, Emad M.; Abdel-Hameed, Reda; Abdelkader, Atef; Abd-Elsalam, Sherief; Abdisa, Wakgari Mosisa; Abdoun, Meriem; Abdous, Arman; Abdulah, Deldar Morad; Abdullahi, Adam; Abdullahi, Auwal; Abdul-Rahman, Toufik; Abdykerimova, Kulmira; Abedi, Armita; Abejew, Asrat Agalu; Abeldaño Zuñiga, Roberto Ariel; Abidi, Syed Hani; Abiodun, Olumide; Abo Kasem, Rahim; Aboagye, Richard Gyan; Abolhassani, Hassan; Abonie, Ulric Sena; Aborode, Abdullahi Tunde; Abourashed, Nagah Mohamed; Abouzid, Mohamed; Abramov, Dmitry; Abreu, Lucas Guimarães; Abtahi, Dariush; Abu Farha, Rana Kamal; Abubakar, Bilyaminu; Abu-Gharbieh, Eman; Abukhadijah, Hana J; Aburuz, Salahdein; Acharya, Anirudh Balakrishna; Achore, Meshack; Acuna, Juan Manuel; Adal, Ousman; Adams, Lisa C.; Adamu, Abdu A; Adebisi, Tajudeen Adesanmi; Adedia, David; Adedokun, Kamoru Ademola; Adegbile, Oluwatobi Emmanuel; Adegboye, Oyelola A; Adegoke, Nurudeen A; Adeleke, Olumide Thomas; Adetunji, Juliana Bunmi; Adhana, Mache Tsadik; Adhikary, Ripon Kumar; Adiga, Usha; Adnan, Mohd; Adnani, Qorinah Estiningtyas Sakilah; Adoma, Prince Owusu; Adzigbli, Leticia Akua; Affinito, Giuseppina; Afolabi, Aanuoluwapo Adeyimika; Afolabi, Habeeb Abiodun; Afolabi, Rotimi Felix; Afzal, Saira; Agampodi, Suneth Buddhika; Agarwal, Dhiraj Motilal; Aghajanian, Sepehr; Aguilera Arriagada, Constanza Elizabeth; Agyemang-Duah, Williams; Ahadi, Mahsa; Ahmad, Aqeel; Ahmad, Danish; Ahmad, Khurshid; Ahmad, Rabbiya; Ahmad, Shoaib; Ahmad, Tauseef; Ahmed, Ayman; Ahmed, Haroon; Ahmed, Meqdad Saleh; Ahmed, Muktar Beshir; Ahmed, Mushood; Ahmed, Naveed; Ahmed, Syed Anees; Ajakwe, Simeon O - 2025 - 1.1 Articolo in rivista)