Location: VIA LUCA GHINI 13, 56126 PISA
Email: stefano.landi@unipi.it
Phone: 050 2211528
Website: www.stefanolandi.eu
Profile
Position: Professore Ordinario
Unit: Dipartimento di Biologia
Scientific-disciplinary sector: Genetica BIOS-14/A
Curriculum of the scientific and teaching activity of Dr. Stefano Landi
Courses and education:
• 1981/82 –1985/86: High School (Diploma di Maturitá Scientifica)
• 1986/87 –1990/91: Master degree in Biological Sciences (Laurea in Scienze Biologiche)
University of Pisa, Facolty of Sciences
Final score: 110/110 + laudem
• 1991/92: Post-lauream training and subscription to the professional register of the biologists.
• 1991/92 – 1993/94: Ph D. (1) in Genetics
University of Ferrara
• November 1994 October 1996: Post-doctoral fellowship
October 1996 - March 1997: Fellowship (Finnish Institute of Occupational Health, Helsinki, Finland)
• Avril 1997 - Avril 1999: Fellowships
University of Pisa
• February 1998 – February 2000: Post Doctoral position, Associateship Award
US Environmental Protection Agency (USEPA), Research Triangle Park, North Carolina, USA.
Tutor: Dr. David DeMarini, Ph. D.
• February – November 2000: Post Doctoral position, Special Training Award
International Agency for Research on Cancer (IARC).
Tutor: Dr. Federico Canzian
• December 2000 – November 2002 : Post-doctoral position, Marie-Curie Individual Fellowship (HPMFCT-2000-00483).
IARC, Lione, Francia.
Tutor: Dr. Federico Canzian
• November 1999 – July 2001 : Specializing school in Applied Genetics
University of Pisa.
Final score: 110/110 + laudem
• 1/5/2001 – 1/5/2004: Short-term position of Scientist Researcher. Genetics, University of Pisa.
• Since 1/5/2004 – 31/12/2011: Permanent position of Scientist Researcher. Genetics, University of Pisa.
• 1/1/2012 - 31/12/2015: Associate professor of Genetics (SSD BIO/18). University of Pisa.
• 1/1/2016 - present: Full professor of Genetics (SSD BIO/18). University of Pisa.
Research grants:
1) Marie-Curie Reintegration Grant della Commissione Europea (MERG-CT-2004-506373)
2) Contract with “Fondazione Buzzi” Prot. 180 del 2/7/2004
3) AIRC- Regional Grants. N. 1082 del 2005-2007. Co-investigator.
4) AIRC- Principal Investigator Grant. N. 1714 del 2005-2006
5) NCI (NIH-USA) Grant code R03CA115062, anno 2006-2008. Principal Investigator. Small grants in cancer epidemiology.
6) AIRC- Principal Investigator Grant. N. 4601 del 2008-2011
7) Donation for research from “Fondazione Buzzi” Prot. 156 del 25/02/2010 (cod. P22)
8) Italian Ministry of Research, PRIN grant 2009-2012
9) 2004-2016. Regular budget, University of Pisa
10) ITT, Tuscany Research Institute of Research on Cancer (2014-2017). Project title: “Variation in miRNA genes and in miRNA binding sites of DNA repair genes as diagnostic, predictive and prognostic factors of colorectal cancer”
11) PRA projects program (University of Pisa). PRA_2016_21, year 2015-2016
12) 05/2017-2020 Fondazione Pisa. Diatec-Meso. PI research grant system.
13) AIRC, Italian Association for Research on Cancer (2019-), 5 years Investigator Grant
Teaching activity:
• Years 2002-2003: “Genetics II” (for the Master degree in Biological Science, University of Pisa, 5 credits).
• Years 2003-2004: “Genetic Engineering” (for the Bachelor degree in Biological and Molecular Biology, University of Pisa, 6 credits).
• Years 2004-2010: “Structural and Functional Genomics” (for the Master degree in Biomolecular sciences and technologies, University of Pisa, 5 credits).
• Years 2009-2016: “Genetics and Genomics analyses” (for the Master degree in Cellular and Molecular Biology, University of Pisa, 6 credits).
• Years 2011-2014: “General Biology” (for the Bachelor degree in Natural Sciences, University of Pisa, 6 credits)
• Years 2015-present: “Genetics” (for the Bachelor degree in Biological Sciences, University of Pisa, 9 credits)
• Year 2016-present: “Neurogenomics” (for the Master Degree in Neurosciences, University of Pisa, 3 credits)
• Year 2018: “Genetics” (for the Bachelor degree in Biotechnologies, University of Pisa, 6 credits)
Courses and education:
• 1981/82 –1985/86: High School (Diploma di Maturitá Scientifica)
• 1986/87 –1990/91: Master degree in Biological Sciences (Laurea in Scienze Biologiche)
University of Pisa, Facolty of Sciences
Final score: 110/110 + laudem
• 1991/92: Post-lauream training and subscription to the professional register of the biologists.
• 1991/92 – 1993/94: Ph D. (1) in Genetics
University of Ferrara
• November 1994 October 1996: Post-doctoral fellowship
October 1996 - March 1997: Fellowship (Finnish Institute of Occupational Health, Helsinki, Finland)
• Avril 1997 - Avril 1999: Fellowships
University of Pisa
• February 1998 – February 2000: Post Doctoral position, Associateship Award
US Environmental Protection Agency (USEPA), Research Triangle Park, North Carolina, USA.
Tutor: Dr. David DeMarini, Ph. D.
• February – November 2000: Post Doctoral position, Special Training Award
International Agency for Research on Cancer (IARC).
Tutor: Dr. Federico Canzian
• December 2000 – November 2002 : Post-doctoral position, Marie-Curie Individual Fellowship (HPMFCT-2000-00483).
IARC, Lione, Francia.
Tutor: Dr. Federico Canzian
• November 1999 – July 2001 : Specializing school in Applied Genetics
University of Pisa.
Final score: 110/110 + laudem
• 1/5/2001 – 1/5/2004: Short-term position of Scientist Researcher. Genetics, University of Pisa.
• Since 1/5/2004 – 31/12/2011: Permanent position of Scientist Researcher. Genetics, University of Pisa.
• 1/1/2012 - 31/12/2015: Associate professor of Genetics (SSD BIO/18). University of Pisa.
• 1/1/2016 - present: Full professor of Genetics (SSD BIO/18). University of Pisa.
Research grants:
1) Marie-Curie Reintegration Grant della Commissione Europea (MERG-CT-2004-506373)
2) Contract with “Fondazione Buzzi” Prot. 180 del 2/7/2004
3) AIRC- Regional Grants. N. 1082 del 2005-2007. Co-investigator.
4) AIRC- Principal Investigator Grant. N. 1714 del 2005-2006
5) NCI (NIH-USA) Grant code R03CA115062, anno 2006-2008. Principal Investigator. Small grants in cancer epidemiology.
6) AIRC- Principal Investigator Grant. N. 4601 del 2008-2011
7) Donation for research from “Fondazione Buzzi” Prot. 156 del 25/02/2010 (cod. P22)
8) Italian Ministry of Research, PRIN grant 2009-2012
9) 2004-2016. Regular budget, University of Pisa
10) ITT, Tuscany Research Institute of Research on Cancer (2014-2017). Project title: “Variation in miRNA genes and in miRNA binding sites of DNA repair genes as diagnostic, predictive and prognostic factors of colorectal cancer”
11) PRA projects program (University of Pisa). PRA_2016_21, year 2015-2016
12) 05/2017-2020 Fondazione Pisa. Diatec-Meso. PI research grant system.
13) AIRC, Italian Association for Research on Cancer (2019-), 5 years Investigator Grant
Teaching activity:
• Years 2002-2003: “Genetics II” (for the Master degree in Biological Science, University of Pisa, 5 credits).
• Years 2003-2004: “Genetic Engineering” (for the Bachelor degree in Biological and Molecular Biology, University of Pisa, 6 credits).
• Years 2004-2010: “Structural and Functional Genomics” (for the Master degree in Biomolecular sciences and technologies, University of Pisa, 5 credits).
• Years 2009-2016: “Genetics and Genomics analyses” (for the Master degree in Cellular and Molecular Biology, University of Pisa, 6 credits).
• Years 2011-2014: “General Biology” (for the Bachelor degree in Natural Sciences, University of Pisa, 6 credits)
• Years 2015-present: “Genetics” (for the Bachelor degree in Biological Sciences, University of Pisa, 9 credits)
• Year 2016-present: “Neurogenomics” (for the Master Degree in Neurosciences, University of Pisa, 3 credits)
• Year 2018: “Genetics” (for the Bachelor degree in Biotechnologies, University of Pisa, 6 credits)
Teaching
Teaching activity
Teaching responsibility for modules/courses
- Genetica (modulo dell'insegnamento biologia generale cod. 311ee) per Laurea in Scienze naturali e ambientali
- Biology (cod. EE067) per Corso Singolo in Foundation course science
- Genetica (cod. 082EE) per Laurea in Scienze biologiche
Student consultation hours
Mode of office hours:
L'orario di ricevimento e' libero previo appuntamento via e-mail.
Verificare anche sul sito
www.stefanolandi.eu
Location: Via Derna, 1 (secondo piano).
Time: L'orario di ricevimento e' libero previo appuntamento via e-mail.
Research
Publications
- Cephalomannine as in vitro and in vivo anticancer agent in mesothelioma cells: mechanisms of action (Morani, F.; Dell'Anno, I.; Daga, A.; Doccini, S.; Bisceglia, L.; Gemignani, F.; Landi, S. - 2025 - 1.1 Articolo in rivista)
- Reproductive Factors, Sex Hormone Levels, and Differentiated Thyroid Cancer Risk: A Mendelian Randomization Study (Park, See Hyun; Sugier, Pierre-Emmanuel; Asgari, Yazdan; Karimi, Mojgan; Kaaks, Rudolf; Fortner, Renée Turzanski; Schulze, Matthias; Agnoli, Claudia; Pasanisi, Fabrizio; Sacerdote, Carlotta; Rodriguez-Barranco, Miguel; Aizpurua, Amaia; Cabrera Castro, Natalia; Guevara, Marcela; Tin Tin, Sandar; Weiderpass, Elisabete; De Vathaire, Florent; Lesueur, Fabienne; Guénel, Pascal; Mulot, Claire; Laurent-Puig, Pierre; Ostroumova, Evgenia; Boland-Auge, Anne; Deleuze, Jean-François; Thomsen, Hauke; Försti, Asta; Elisei, Rosella; Gemignani, Federica; Landi, Stefano; Rinaldi, Sabina; Elbaz, Alexis; Domenighetti, Cloé; Truong, Thérèse - 2025 - 1.1 Articolo in rivista)
- Computational modeling and experimental validation of the interaction between tumor biomarker mesothelin and an engineered targeting protein with therapeutic activity (Piccardi, Margherita; Butera, Valeria; Sardo, Ignazio; Landi, Stefano; Gemignani, Federica; Barone, Giampaolo; Spinello, Angelo; Moore, Sarah J. - 2025 - 1.1 Articolo in rivista)
- Identification of 4 autophagy-related genetic variants as risk factors for chronic lymphocytic leukemia (Cabrera-Serrano, Antonio José; Sánchez-Maldonado, José Manuel; Rodríguez-Sevilla, Juan José; Reyes-Zurita, Fernando Jesús; Collado, Rosa; Puiggros, Anna; Cornejo-Calvo, Elena; García-Martín, Paloma; Ter Horst, Rob; Benavente, Yolanda; Jerez, Andrés; Landi, Stefano; Espinet, Blanca; Maffei, Rossana; López-Nevot, Miguel Ángel; Ramos-Campoy, Silvia; González-Olmedo, Carmen; Chen-Liang, Tzu-Hua; Moreno, Víctor; Jannus, Fatin; Marcos-Gragera, Rafael; Carretero-Fernández, María; Sampaio-Marques, Belém; Gámez, Irene; García-Álvarez, María; Camp, Nicola J; Dierssen-Sotos, Trinidad; Kamaso, Joanna; Pérez, Eva María; Norman, Aaron D; Luppi, Mario; Li, Yang; Alcoceba, Miguel; Campa, Daniele; De San José, Silvia; Marasca, Roberto; Ludovico, Paula; Clay-Gilmour, Alyssa; Canzian, Federico; Ibañez, Marian; Netea, Mihai G; Mckay, James; Casabonne, Delphine; Berndt, Sonja I; Slager, Susan L; Sainz, Juan - 2025 - 1.1 Articolo in rivista)
- Development of a Mesothelin-Binding Engineered Scaffold Protein as a Theranostic for Pleural Mesothelioma (Silvestri, Roberto; Piccardi, Margherita; Laurenza, Alessia; Rea, Filomena; Sirois, Allison R.; Lari, Martina; Bartoli, Francesco; Signore, Giovanni; Tedeschi, Lorena; Ferraro, Elisabetta; Erba, Paola Anna; Giovannoni, Roberto; Landi, Stefano; Gemignani, Federica; Moore, Sarah J. - 2025 - 1.1 Articolo in rivista)
- Decoding the role of mesothelin in tumor dynamics and targeted treatment innovations (Silvestri, Roberto; Colucci, Emanuela; Piccardi, Margherita; Landi, Stefano; Gemignani, Federica - 2025 - 1.1 Articolo in rivista)
- Transcriptomic Profiling of the Tumor Microenvironment in High-Grade Serous Carcinoma: A Pilot Study of Morphologic and Molecular Distinctions Between Classic and SET Patterns (Giannini, Riccardo; Bartoli, Francesco; Ieso, Katia De; Camacci, Tiziano; Bertolucci, Andrea; Piccini, Lorenzo; Rreka, Erion; Volterrani, Duccio; Gemignani, Federica; Landi, Stefano; Ugolini, Clara; Lippolis, Piero Vincenzo; Faviana, Pinuccia - 2025 - 1.1 Articolo in rivista)
- The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC (Peduzzi, Giulia; Archibugi, Livia; Farinella, Riccardo; De Leon Pisani, Ruggero Ponz; Vodickova, Ludmila; Vodicka, Pavel; Kraja, Bledar; Sainz, Juan; Bars-Cortina, David; Daniel, Neil; Silvestri, Roberto; Uysal-Onganer, Pinar; Landi, Stefano; Dulinska-Litewka, Joanna; Comandatore, Annalisa; Campa, Daniele; Hughes, David J.; Rizzato, Cosmeri - 2025 - 1.1 Articolo in rivista)
- Body Mass Index and Sporadic Medullary Thyroid Cancer: Insights from a Large Series (Prete, Alessandro; Gambale, Carla; Bottici, Valeria; Cappagli, Virginia; Aringhieri, Giacomo; Puccini, Marco; Landi, Stefano; Torregrossa, Liborio; Santini, Ferruccio; Matrone, Antonio; Elisei, Rossella - 2025 - 1.1 Articolo in rivista)
- Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization (Gálvez-Montosa, Fernando; Peduzzi, Giulia; Sanchez-Maldonado, José Manuel; Ter Horst, Rob; Cabrera-Serrano, Antonio J; Gentiluomo, Manuel; Macauda, Angelica; Luque, Natalia; Ünal, Pelin; García-Verdejo, Francisco José; Li, Yang; López López, José Antonio; Stein, Angelika; Bueno-de-Mesquita, H Bas; Arcidiacono, Paolo Giorgio; Zanette, Dalila Luciola; Kahlert, Christoph; Perri, Francesco; Soucek, Pavel; Talar-Wojnarowska, Renata; Theodoropoulos, George E; Izbicki, Jakob R; Tamás, Hussein; Van Laarhoven, Hanneke; Nappo, Gennaro; Petrone, Maria Chiara; Lovecek, Martin; Vermeulen, Roel C H; Adamonis, Kestutis; Reyes-Zurita, Fernando Jesus; Holleczek, Bernd; Sumskiene, Jolanta; Mohelníková-Duchonová, Beatrice; Lawlor, Rita T; Pezzilli, Raffaele; Aoki, Mateus Nobrega; Pasquali, Claudio; Petrenkiene, Vitalija; Basso, Daniela; Bunduc, Stefania; Comandatore, Annalisa; Brenner, Hermann; Ermini, Stefano; Vanella, Giuseppe; Goetz, Mara R; Archibugi, Livia; Lucchesi, Maurizio; Uzunoglu, Faik Guntac; Busch, Olivier; Milanetto, Anna Caterina; Puzzono, Marta; Kupcinskas, Juozas; Morelli, Luca; Sperti, Cosimo; Carrara, Silvia; Capurso, Gabriele; van Eijck, Casper H J; Oliverius, Martin; Roth, Susanne; Tavano, Francesca; Kaaks, Rudolf; Szentesi, Andrea; Vodickova, Ludmila; Luchini, Claudio; Schöttker, Ben; Landi, Stefano; Dohan, Orsolya; Tacelli, Matteo; Greenhalf, William; Gazouli, Maria; Neoptolemos, John P; Cavestro, Giulia Martina; Boggi, Ugo; Latiano, Anna; Hegyi, Péter; Ginocchi, Laura; Netea, Mihai G; Sánchez-Rovira, Pedro; Canzian, Federico; Campa, Daniele; Sainz, Juan - 2025 - 1.1 Articolo in rivista)
- BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma (Bisceglia, Luisa; Morani, Federica; Guerrieri, Lara; Santoni-Rugiu, Eric; Çakilkaya, Pinar; Scatena, Cristian; Scarpitta, Rosa; Engelholm, Lars H.; Behrendt, Niels; Gemignani, Federica; Landi, Stefano - 2024 - 1.1 Articolo in rivista)
- Comparative analysis of genetic variants in pleural fluids and solid tissue biopsies of pleural mesothelioma patients: Implications for molecular heterogeneity assessment (Silvestri, Roberto; Rea, Filomena; Vitiello, Marianna; Moretti, Gabriele; Aprile, Vittorio; Lucchi, Marco; Aretini, Paolo; Mazzanti, CHIARA MARIA; Landi, Stefano; Gemignani, Federica - 2024 - 1.1 Articolo in rivista)
- Polymorphism Pro64His within galectin-3 has functional consequences at proteome level in thyroid cells (Silvestri, Roberto; Zallocco, Lorenzo; Corrado, Alda; Ronci, Maurizio; Aceto, Romina; Ricci, Benedetta; Cipollini, Monica; Dell'Anno, Irene; De Simone, Chiara; De Marco, Giuseppina; Ferrarini, Eleonora; Beghelli, Daniela; Mazzoni, Maria Rosa; Lucacchini, Antonio; Gemignani, Federica; Giusti, Laura; Landi, Stefano - 2024 - 1.1 Articolo in rivista)
- Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk (Ünal, Pelin; Lu, Ye; Bueno-de-Mesquita, Bas; van Eijck, Casper H. J.; Talar-Wojnarowska, Renata; Szentesi, Andrea; Gazouli, Maria; Kreivenaite, Edita; Tavano, Francesca; Malecka-Wojciesko, Ewa; Eross, Bálint; Oliverius, Martin; Bunduc, Stefania; Nóbrega Aoki, Mateus; Vodickova, Ludmila; Boggi, Ugo; Giaccherini, Matteo; Kondrackiene, Jurate; Chammas, Roger; Palmieri, Orazio; Theodoropoulos, George E.; Bijlsma, Maarten F.; Basso, Daniela; Mohelnikova-Duchonova, Beatrice; Soucek, Pavel; Izbicki, Jakob R.; Kiudelis, Vytautas; Vanella, Giuseppe; Arcidiacono, Paolo Giorgio; Wlodarczyk, Barbara; Hackert, Thilo; Schöttker, Ben; Uzunoglu, Faik G.; Bambi, Franco; Goetz, Mara; Hlavac, Viktor; Brenner, Hermann; Perri, Francesco; Carrara, Silvia; Landi, Stefano; Hegyi, Péter; Dijk, Frederike; Maiello, Evaristo; Capretti, Giovanni; Testoni, Sabrina Gloria Giulia; Petrone, Maria Chiara; Stocker, Hannah; Ermini, Stefano; Archibugi, Livia; Gentiluomo, Manuel; Cavestro, Giulia Martina; Pezzilli, Raffaele; Di Franco, Gregorio; Milanetto, Anna Caterina; Sperti, Cosimo; Neoptolemos, John P.; Morelli, Luca; Vokacova, Klara; Pasquali, Claudio; Lawlor, Rita T.; Bazzocchi, Francesca; Kupcinskas, Juozas; Capurso, Gabriele; Campa, Daniele; Canzian, Federico - 2024 - 1.1 Articolo in rivista)
- Strategies for single base gene editing in an immortalized human cell line by CRISPR/Cas9 technology (Corrado, Alda; Aceto, Romina; Miglietta, Simona; Silvestri, Roberto; Dell'Anno, Irene; Lepori, Irene; Ricci, Benedetta; Romei, Cristina; Giovannoni, Roberto; Poliseno, Laura; Evangelista, Monica; Vitiello, Marianna; Cipollini, Monica; Elisei, Rossella; Landi, Stefano; Gemignani, Federica - 2024 - 1.1 Articolo in rivista)