Profile
Teaching
Teaching activity
Teaching responsibility for modules/courses
- Cip - biostrumentazioni e biostatistica per le scienze motorie (cod. 1198I) per Laurea in Scienze motorie
Insegnamenti condivisi/mutuati:- Cip - biostrumentazioni e biostatistica per le scienze motorie (cod. 1198I) - Laurea in Scienze motorie
- Modelli compartimentali (modulo dell'insegnamento modelli compartimentali ed organi artificiali cod. 843ii) per Laurea in Ingegneria biomedica
- Biomeccanica (modulo dell'insegnamento fisiologia e biomeccanica applicate agli ambienti estremi cod. 0030e) per Laurea in Scienze motorie
- Biologia computazionale - mod. a (modulo dell'insegnamento meet - biologia computazionale cod. 005fi) per Laurea Magistrale Ciclo Unico 6 anni in Medicina e chirurgia
- Tecnologie bioingegneristiche applicate alla medicina - corso ak (modulo dell'insegnamento metodi innovativi di studio, di ricerca e comunicazione in ambito biomedico cod. 0073f) per Laurea Magistrale Ciclo Unico 6 anni in Medicina e chirurgia
- Tecnologie biomediche (modulo dell'insegnamento protesi impiantabili, fitting e tecnologie biomediche cod. 010if) per Laurea in Tecniche audioprotesiche (abilitante alla professione sanitaria di audioprotesista)
Research
Research interests
he overarching goal of our research group is to elucidate the physiological mechanisms that govern weight gain and weight loss, to identify novel strategies to prevent weight gain, to support more effective weight loss in individuals with overweight, and to mitigate the adverse consequences of excess adiposity. To pursue these aims, one major line of research focuses on the development and validation of new methods and technologies to assess and monitor energy expenditure and energy intake under free living conditions over extended time periods.
A second line of research investigates the determinants of energy balance, namely energy intake and energy expenditure, and their contribution to changes in body weight. In particular, we aim to identify and characterize human metabolic phenotypes, including “spendthrift” versus “thrifty” profiles, and preferential substrate utilization patterns (predominant carbohydrate versus fat oxidation). These phenotypes are examined through measurements of energy metabolism during controlled overfeeding and caloric restriction, with the goal of understanding interindividual differences in susceptibility to weight gain and weight loss. We also study genetic determinants of energy metabolism and resting metabolic rate that may contribute to individual predisposition to obesity.
Publications
- Human Physiologic Responses to Insulin in Indigenous Americans Identify a Metabolic Susceptibility Profile Linked to Diabetes (Murthy, Venkatesh L; Piaggi, Paolo; Lin, Phillip; Zhao, Shilin; Stolze, Lindsey K; Perry, Andrew S; Hanson, Robert L; Carr, John Jeffrey; Terry, James G; Baier, Leslie J; Bogardus, Clifton; Clish, Clary; Gamazon, Eric R; Krakoff, Jonathan; Shah, Ravi V - 2025 - 1.1 Articolo in rivista)
- An E115A missense variant in CERS2 is associated with increased sleeping energy expenditure and hepatic insulin resistance in American Indians (Heinitz, Sascha; Traurig, Michael; Krakoff, Jonathan; Rabe, Philipp; Stäubert, Claudia; Kobes, Sayuko; Hanson, Robert L; Stumvoll, Michael; Blüher, Matthias; Bogardus, Clifton; Baier, Leslie; Piaggi, Paolo - 2024 - 1.1 Articolo in rivista)
- Derivation of the effective air volume of indirect room calorimeters: An uncertainty-based approach (Bandini, Gabriele; Landi, Alberto; Santini, Ferruccio; Basolo, Alessio; Marracci, Mirko; Piaggi, Paolo - 2024 - 1.1 Articolo in rivista)
- Closed-loop control of air supply to whole-room indirect calorimeters to improve accuracy and standardize measurements during 24-hour dynamic metabolic studies (Piaggi, Paolo; Rodzevik, Theresa L; Wohlers, Erica; Ruud, Katherine; Moon, Jon; Krakoff, Jonathan; Chang, Douglas C - 2023 - 1.1 Articolo in rivista)
- The counterbalancing effects of energy expenditure on body weight regulation: Orexigenic versus energy-consuming mechanisms (Piaggi, Paolo; Basolo, Alessio; Martin, Corby K.; Redman, Leanne M.; Votruba, Susanne B.; Krakoff, Jonathan - 2022 - 1.1 Articolo in rivista)
- Reduced adaptive thermogenesis during acute protein-imbalanced overfeeding is a metabolic hallmark of the human thrifty phenotype (Hollstein, Tim; Basolo, Alessio; Ando, Takafumi; Krakoff, Jonathan; Piaggi, Paolo - 2021 - 1.1 Articolo in rivista)
- Impaired Metabolic Flexibility to High-fat Overfeeding Predicts Future Weight Gain in Healthy Adults (Begaye, Brittany; Vinales, Karyne L; Hollstein, Tim; Ando, Takafumi; Walter, Mary; Bogardus, Clifton; Krakoff, Jonathan; Piaggi, Paolo - 2020 - 1.1 Articolo in rivista)
- Metabolic response to fasting predicts weight gain during low-protein overfeeding in lean men: further evidence for spendthrift and thrifty metabolic phenotypes (Hollstein, T; Ando, T; Basolo, A; Krakoff, J; Votruba, Sb; Piaggi, P - 2019 - 1.1 Articolo in rivista)
- Metabolic Determinants of Weight Gain in Humans (Piaggi, Paolo - 2019 - 1.1 Articolo in rivista)
- FGF21 is a Hormonal Mediator of the Human "Thrifty" Metabolic Phenotype (Vinales, Karyne L; Begaye, Brittany; Bogardus, Clifton; Walter, Mary; Krakoff, Jonathan; Piaggi, Paolo - 2019 - 1.1 Articolo in rivista)