Filippo Sean Giorgi

Attività didattica

Incarichi di responsabilità didattica di moduli/insegnamenti

Registro lezioni

Orario lezioni

Ricevimento

Modalità:

Luogo: su piattaforma telematica, previa mail a filippo.giorgi@unipi.it

Orario: Mercoledì ore 14.30-16.30

Interessi di ricerca

Filippo Giorgi is an M.D. and Ph.D., and a specialist in Neurology. He completed his training at the University of Pisa, the Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna (Pisa, Italy), and the Albert Einstein College of Medicine (New York, USA). He completed his Neurology residency at the University of Pisa.
Following his residency, he continued conducting research on experimental models of neurological disorders while also practicing as a neurologist at the Neurology Unit of the Pisa University Hospital. There, he was involved in both clinical and research activities within the Memory Clinic and Epilepsy Center until 2019, when he assumed his current full-time academic position.
Throughout his training and career, his research has focused on neuroscience with both basic and translational approaches. One of his primary research interests, originating during his Ph.D. studies, has been the involvement of the Locus Coeruleus in neurological disorders. Using models of Locus Coeruleus degeneration, he has contributed to studies investigating its role in experimental neurodegeneration. He has been particularly involved in analyzing the effects of Locus Coeruleus lesions on experimental limbic seizures. In recent years, he has extended this research to human studies—especially in Alzheimer's disease patients—through a project funded by a competitive grant from the Italian Ministry of Health, for which he served as PI and coordinator.
His current research explores the role of subcortical structures in pathological aging, their involvement in experimental epilepsy, and—more recently—their role in seizure susceptibility in children with infantile post-hypoxic epilepsy, profiting of the specific fundings of an ad-hoc competitive Grant. These studies are conducted in collaboration with the Neuroradiology and Epilepsy Units of the IRCCS Stella Maris Foundation, and involve experimental models, including mice and, more recently, zebrafish (collaborating with IIT-Genua- and the Department of Biology of Pisa University). For these experimental models, he primarily employs morphological techniques, such as optical microscopy (immunofluorescence and immunohistochemistry with quantitative post-hoc analysis, including the use of Stereo Investigator hardware and software), electron microscopy, and EEG analysis.

Pubblicazioni

• Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia (Galgani, Alessandro; Lombardo, Francesco; Martini, Nicola; Vergallo, Andrea; Bastiani, Luca; Hampel, Harald; Hlavata, Hana; Baldacci, Filippo; Tognoni, Gloria; De Marchi, Daniele; Ghicopulos, Irene; De Cori, Sara; Biagioni, Francesca; Busceti, Carla Letizia; Ceravolo, Roberto; Bonuccelli, Ubaldo; Chiappino, Dante; Siciliano, Gabriele; Fornai, Francesco; Pavese, Nicola; Giorgi, Filippo Sean - 2023 - 1.1 Articolo in rivista)
• Brain metabolic correlates of Locus Coeruleus degeneration in Alzheimer's disease: a multimodal neuroimaging study (Aghakhanyan, Gayane; Galgani, Alessandro; Vergallo, Andrea; Lombardo, Francesco; Martini, Nicola; Baldacci, Filippo; Tognoni, Gloria; Leo, Andrea; Guidoccio, Federica; Siciliano, Gabriele; Fornai, Francesco; Pavese, Nicola; Volterrani, Duccio; Giorgi, Filippo S. - 2023 - 1.1 Articolo in rivista)
• Biological determinants of blood-based cytokines in the Alzheimer's Disease clinical continuum (Galgani, A; Vergallo, A; Campese, N; Lombardo, F; Pavese, N; Petrozzi, L; Logerfo, A; Franzini, M; Cecchetti, D; Puglisi-Allegra, S; Busceti, C L; Siciliano, G; Tognoni, G; Baldacci, F; Lista, S; Hampel, H; Fornai, F; Giorgi, F S - 2022 - 1.1 Articolo in rivista)
• Prolonged epileptic discharges predict seizure recurrence in JME: Insights from prolonged ambulatory EEG (Turco, F.; Bonanni, E.; Milano, C.; Pizzanelli, C.; Steinwurzel, C.; Morganti, R.; Fornai, F.; Maestri, M.; Siciliano, G.; Giorgi, F. S. - 2021 - 1.1 Articolo in rivista)
• Sex dimorphism in seizure-controlling networks (Giorgi, F. S.; Galanopoulou, A. S.; Moshe, S. L. - 2014 - 1.1 Articolo in rivista)
• What is the role for EEG after sleep deprivation in the diagnosis of epilepsy? Issues, controversies, and future directions. (Giorgi, F; Guida, Melania; Caciagli, L; Maestri, Michelangelo; Carnicelli, Luca; Bonanni, Enrica; Bonuccelli, Ubaldo - 2014 - 1.1 Articolo in rivista)
• The role of substantia nigra pars reticulata in modulating clonic seizures is determined by testosterone levels during the immediate postnatal period (Giorgi, F. S.; Veliskova, J.; Chudomel, O.; Kyrozis, A.; Moshe, S. L. - 2007 - 1.1 Articolo in rivista)
• Effects of status epilepticus early in life on susceptibility to ischemic injury in adulthood (Giorgi, F. S.; Malhotra, S.; Hasson, H.; Veliskova, J.; Rosenbaum, D. M.; Moshe, S. L. - 2005 - 1.1 Articolo in rivista)
• Previous exposure to [+/-] 3,4-methylenedioxymethamphetamine produces long-lasting alteration in limbic brain excitability measured by electroencephalogram spectrum analysis, brain metabolism and seizure susceptibility. (Giorgi, Fs; Pizzanelli, C; Ferrucci, Michela; Lazzeri, Gloria; Faetti, M; Giusiani, Mario; Pontarelli, F; Busceti, Cl; Murri, Luigi; Fornai, Francesco - 2005 - 1.1 Articolo in rivista)
• A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus (Giorgi, Fs; Ferrucci, Michela; Lazzeri, Gloria; Pizzanelli, C; Lenzi, Paola; Alessandri, Mg; Murri, Luigi; Fornai, Francesco - 2003 - 1.1 Articolo in rivista)

Tutte le pubblicazioni di Filippo Sean Giorgi su ARPI, l'archivio della Ricerca dell'Università di Pisa