GIOTTO

 

giottologoUnipi Team Leader: Prof. Giovanni Vozzi, Dip. Ingegneria dell'Informazione

 

Osteoporosis is a systemic, degenerative disorder, predominantly affecting postmenopausal women (1 out of 3) but also men at an advanced age (1 out of 5) and it increases the prevalence of fracture risk. One fifth of people suffering an osteoporotic fracture will die within a year and half will become dependent. Appropriate anti-osteoporotic drugs are available but have serious side effects and they do not promote fracture healing.


The concept behind GIOTTO is to develop a platform of technologies and materials for the treatment of different types of osteoporotic fractures, designing, manufacturing and validating three different solutions:

  1.  3D graded scaffold, which can be fixated with screws, to treat long bone fractures 
  2. Fibrous scaffold to deal with small, not confined pelvic fractures;
  3. Radiopaque, bioresorbable, injectable cement to stabilise vertebral fractures.

The three devices will share smart nanobiomaterials that release chemical and biological cues to stimulate bone regeneration while reducing bone loss.

Nanofunctionalisation and the smart, temporalised release of active molecules will allow for the systematic cell recruitment and activation needed to face the challenges of stimulating bone tissue regeneration in the elderly.  The use of additive manufacturing technologies will enable device personalisation to match and better align with the patient’s anatomy and fracture type.

A further boost to meet patient specificity and needs, will be provided through the use of functionalised magnetic nanoparticles in order to provide, via the application of an external oscillating magnetic field, a remote tool to activate mechanotransduction. In parallel, an Internet of Things platform will be developed to gather and collate measurable data inputs about device effectiveness and to provide decision support software as a service to improve the design, manufacture and clinical function of the proposed devices, ultimately managing the overall value chain.

 

Coordinator:

POLITECNICO DI TORINO

 

Other Participants:

  • UNIVERSITA DI PISA (Italy)
  • UNIVERSITEIT MAASTRICHT (Netherlands)
  • UNIVERSIDAD COMPLUTENSE DE MADRID (Spain)
  • FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (Greece)
  • UNIVERSITY OF NEWCASTLE UPON TYNE (United Kingdom)
  • DUBLIN CITY UNIVERSITY (Ireland)
  • BEWARRANT (Belgium)
  • CELLINK AB (Sweden)
  • BIOMECH INNOVATIONS AG (Switzerland)
  • FLUIDINOVA SA (Portugal)
  • TECNOLOGIA NAVARRA DE NANOPRODUCTOS SL (Spain)
  • NOVAICOS SRLS (Italy)
  • YODIWO ANONYMI ETAIREIA SCHEDIASISOLOKLIROMENON KYKLOMATON (Greece)

 

Start Date 1/1/2019

End Date 28/02/2023

Project Cost € 5 660 096,25

Project Funding € 5 660 096,25

Call Title H2020-NMBP-TR-IND-2018

UNIPI Quota € 332 000

UNIPI Role: Participant

Website: https://www.giottoproject.eu/ 

 

 

 

 

Ultima modifica: Lun 19 Ott 2020 - 09:35

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