{"id":151117,"date":"2025-05-12T14:15:17","date_gmt":"2025-05-12T14:15:17","guid":{"rendered":"https:\/\/www.unipi.it\/ateneo\/organizzazione\/persone\/alma-martelli-12967-en\/"},"modified":"2026-04-01T04:45:32","modified_gmt":"2026-04-01T02:45:32","slug":"alma-martelli-12967-en","status":"publish","type":"unipi_persone","link":"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/","title":{"rendered":"Alma Martelli"},"content":{"rendered":"<p>Professore Associato &#8211; Dipartimento di Farmacia | Tel.: 050 2219598 &#8211; Email: alma.martelli@unipi.it<\/p>\n","protected":false},"template":"","meta":{"unipi-persone-chiave":"12967","unipi-persone-nome":"Alma","unipi-persone-cognome":"Martelli","unipi-persone-email":"alma.martelli@unipi.it","unipi-persone-cv":"Prof. Alma Martelli Curriculum vitae:<br \/>\r\n2003: PharmD degree with full score (110 cum Laude). Experimental thesis in pharmacology entitled \u201cPharmacological study on the vasorelaxing activity of novel BK potassium channel activators\u201d. <br \/>\r\n2004: 1-year long fellowship at the Interdipartimental Centre of Clinical Pharmacology and Experimental Therapy, Univ. of Pisa, entitled \u201cPharmacodynamic and pharmacokinetic properties of NO-Sartans in in vitro and in vivo experimental models\u201d. <br \/>\r\n2005-2007: PhD student in \"Science of Pharmaceuticals and Bio-active Compounds\" at Faculty of Pharmacy (Univ. of Pisa). <br \/>\r\n2008: PhD degree (with full score) with a thesis on \u201cNitric Oxide Releasing Multi-target Drugs\u201d. <br \/>\r\n2009: II\u00b0 level Master degree in \u201cClinical Experimentation of Drugs\u201d at Faculty of Medicine and Surgery, Univ.of Pisa. <br \/>\r\n2008-2014: several postdoc fellowships in Pharmacology both at the Dep. of Pharmacy, Univ. of Pisa and at the Biomedical Research Centre, Sheffield-Hallam University, Sheffield (UK), focused on the physio-pharmacological role of gasotransmitters such as nitric oxide (NO) and hydrogen sulfide (H2S) in the cardiovascular (CV) system. <br \/>\r\n2011: principal investigator of the research project \u201cPotassium and Rubidum efflux in vascular smooth muscle after H2S-donors administration\u201d at the Biomedical Research Centre, Sheffield-Hallam University, Sheffield (UK), supported by a SIF (Italian Pharmacological Society) grant.<br \/>\r\n2014-2016: Junior Researcher in Pharmacology (RTDa), Dep. of Pharmacy, Univ. of Pisa<br \/>\r\n2016-2019: Senior Researcher in Pharmacology (RTDb), Dep. of Pharmacy, Univ. of Pisa. <br \/>\r\n2019-today: Associate Professor in Pharmacology at Dep. of Pharmacy, Univ. of Pisa. <br \/>\r\n2022-today: National Scientific Abilitation (ASN) as Full Professor in Pharmacology.<br \/>\r\n2022-today: Member of the committee for the admission of new members of Italian Society of Pharmacology (SIF).<br \/>\r\n2023-today: Director of the School of Specialization in Hospital Pharmacy (SSFo, Univ. of Pisa)2024-today: Vice-Director of the interdepartmental centers: \"Nutraceutic and health nutrition (Nutrafood) and Vice-President of the Degree Course in Pharmacy.<br \/>\r\n2025-today: Member of the Departmental Teaching committee and Delegate for Masters.<br \/>\r\n2025-today: Member of the COST Action CA22169 - EUropean network to tackle METAbolic alterations in HEART failure (EU-METAHEART)<br \/>\r\n2025-today: Member of the Italian Ministry of Health Committee for the attribution of new Pharmacies.<br \/>\r\nResearch activity: potential drugs (natural, e.g. botanical or synthetic) with beneficial effect at CV level; studies on the gasotransmitters NO- and H2S-release, both from exogenous sources (i.e. NO-donor and H2S-donors) and the endogenous biosynthesis. Solid expertise on the role of potassium channels (KATP, Kv7, BKCa) at CV level. Wide expertise on vascular and cardiac systems included cellular models, isolated organs and in vivo animal procedures. CV effects evoked by isothiocyanates, (H2S-donors deriving from Crucifers). <br \/>\r\nAuthor of over 150 articles and 5 book chapters published on international peer reviewed journals or books and of 2 international patents. <br \/>\r\nInvited speaker in several national or international conferences and received several national and international scientific awards. <br \/>\r\nMember of SIF and regional referent of the Italian Nutraceutical Society (SINut), member of the scientific committee of the Italian Society of Nutraceutical Formulators (SIFNut). <br \/>\r\nCo-PI of the UNIPI Unit of the Spoke 4 (Food quality and Nutrition) of the PNRR-grant called PE10:Research and innovation network on food and nutrition Sustainability, Safety and Security Working ON Foods. <br \/>\r\nPI of the UNIPI Unit of the PRIN2022PNRR entitled \"Health promotion and neuropathic pain prevention through glymphatic system modulation: a sex\/gender perspective\". <br \/>\r\nTeaching activity: fundamental courses at the Pharmacy degree course, at the PhD- and SSFO-courses.","unipi-persone-link-esterno-cv":"","unipi-persone-modalita-ricevimento":"Luned\u00ec dalle 15 alle 16. In alternativa mandare una mail per prendere un appuntamento.","unipi-persone-luogo-ricevimento":"","unipi-persone-ore-ricevimento":"","unipi-persone-telefono":"050 2219598","unipi-persone-sitoweb":"www.farm.unipi.it","unipi-persone-cariche":"<ul><li>Direttore di Scuola di Specializzazione - FARMACIA OSPEDALIERA<\/li><li>Vice Direttore di Centro - Centro Interdipartimentale di Ricerca &quot;Nutraceutica e Alimentazione per la Salute&quot;<\/li><\/ul>","unipi-persone-link-orario-lezioni":"https:\/\/unipi.prod.up.cineca.it\/calendarioPubblico\/matricola=011625","unipi-persone-link-registro-lezioni":"https:\/\/unimap.unipi.it\/registri\/registri.php?ri=011625&tmplt=principale.tpl","unipi-persone-settore-scientifico":"Farmacologia BIOS-11\/A","unipi-persone-ruolo":"Professore Associato","unipi-persone-arpi":"https:\/\/arpi.unipi.it\/cris\/rp\/rp07283","unipi-persone-pubblicazioni":"<ul class=\"pubblicazioni-list\"><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1362468\" target=\"_blank\" rel=\"noopener noreferrer\">Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death<\/a> <span class=\"pub-details\">(Citi, V.; Chahna, R.; Maffei, F.; Martelli, A.; Calderone, V.; Fimognari, C.; Turrini, E. - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1362467\" target=\"_blank\" rel=\"noopener noreferrer\">In Vitro and Ex Vivo Evaluation of a Multi-Target Combination of Plant Extracts and Policosanols: Effects in Mitigating Heart Inflammation and Oxidative Stress<\/a> <span class=\"pub-details\">(Recinella, Lucia; Bray, Giorgia; Pia Centulio, Angelica; Ciaramellano, Davide; Chiavaroli, Annalisa; Genovesi, Gianluca; Orlando, Giustino; Acquaviva, Alessandra; Citi, Valentina; Veschi, Serena; Piro, Anna; Cama, Alessandro; Martelli, Alma; Calderone, Vincenzo; Brunetti, Luigi; Leone, Sheila - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1362187\" target=\"_blank\" rel=\"noopener noreferrer\">Thiourea-Based H2S-Releasing Pramipexole Hybrids as Neuroprotective Agents<\/a> <span class=\"pub-details\">(Corvino, Angela; Citi, Valentina; Scognamiglio, Antonia; Martelli, Alma; Calderone, Vincenzo; Neggiani, Giulia; Fimognari, Carmela; Fiorino, Ferdinando; Magli, Elisa; Sparaco, Rosa; Santagada, Vincenzo; Caliendo, Giuseppe; Severino, Beatrice - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1357429\" target=\"_blank\" rel=\"noopener noreferrer\">Improving the compatibility of INFOGEST digesta with intestinal epithelial models through post-digestion storage conditions<\/a> <span class=\"pub-details\">(Troisi, Fabiola; Narra, Federica; Prantera, Antonella; Acciari, Martina; Ballestracci, Chiara; Guerrucci, Beatrice; Piragine, Eugenia; Serra, Andrea; Martelli, Alma; Guidi, Lucia; Ceccanti, Costanza; Giovannoni, Roberto - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1356967\" target=\"_blank\" rel=\"noopener noreferrer\">Glucoerucin, Glucosinolate From Brassicaceae Vegetables, Improves the Metabolic Profile in a Murine Model of Diet-Induced Obesity<\/a> <span class=\"pub-details\">(Flori, L; Spezzini, J; Benedetti, G; Pagnotta, E; Lazzarini, G; Conte, G; Miragliotta, V; Del Debbio, F; Martelli, A; Mannelli, Ldc; Da Pozzo, E; Vellecco, V; Bucci, M; Casale, V; Righetti, L; Ghelardini, C; Testai, L; Calderone, V. - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1353567\" target=\"_blank\" rel=\"noopener noreferrer\">2-Phenylquinolines Exhibit Anti-Severe Acute Respiratory Syndrome Coronavirus-2 Activity Through the Nonstructural Protein 13 Helicase Inhibition<\/a> <span class=\"pub-details\">(Cernicchi, G.; Nizi, M. G.; Emmolo, R.; Persoons, L.; Laporte, M.; Jochmans, D.; Romeo, I.; Pepe, G.; Milite, C.; Campiglia, P.; Spezzini, J.; Martelli, A.; Brogi, S.; Esposito, F.; Felicetti, T.; Massari, S.; Manfroni, G.; Sabatini, S.; Sbardella, G.; Alcaro, S.; Neyts, J.; Corona, A.; Tramontano, E.; De Jonghe, S.; Tabarrini, O. - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1350507\" target=\"_blank\" rel=\"noopener noreferrer\">Potential Efficacy of Polyphenols and Isothiocyanates in the Management of Genitourinary Diseases: A Systematic Review of Preclinical and Clinical Studies<\/a> <span class=\"pub-details\">(Piragine, Eugenia; Moretti, Pasquale; Scarpulla, Salvatore; Calderone, Vincenzo; Martelli, Alma - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1345908\" target=\"_blank\" rel=\"noopener noreferrer\">Microbiota-Mediated Crosstalk Between the Gut and the Vascular System: Protective Effects of Novel Postbiotic Formulations on Human Endothelial and Vascular Smooth Muscle Cells<\/a> <span class=\"pub-details\">(Flori, L.; Squarzanti, D. F.; Lo Re, M.; Malfa, P.; Martelli, A.; Calderone, V. - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1342167\" target=\"_blank\" rel=\"noopener noreferrer\">Glucotropaeolin-enriched Lepidium sativum L. extract as a novel phytotherapy for tendinopathy: mechanistic insights into pain modulation<\/a> <span class=\"pub-details\">(Lucarini, Elena; Pagnotta, Eleonora; Righetti, Laura; Citi, Valentina; Trisolini, Samuele; Ciampi, Clara; Micheli, Laura; Martelli, Alma; Testai, Lara; Calderone, Vincenzo; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1342109\" target=\"_blank\" rel=\"noopener noreferrer\">Semi-Synthetic H2S Releasing Compounds with Antioxidant and Vasorelaxant Properties<\/a> <span class=\"pub-details\">(Citi, Valentina; Fallica, Antonino N.; Salerno, Loredana; Virz\u00ec, Nicola F.; Ciaffaglione, Valeria; Intagliata, Sebastiano; Veneziano, Sara; Benedetti, Giada; Spezzini, Jacopo; Martelli, Alma; Calderone, Vincenzo; Pittal\u00e0, Valeria - 2026 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1343168\" target=\"_blank\" rel=\"noopener noreferrer\">Naturally Occurring H2S-Donors in Vascular Diseases<\/a> <span class=\"pub-details\">(Flori, Lorenzo; Spezzini, Jacopo; Piragine, Eugenia; Citi, Valentina; Calderone, Vincenzo; Martelli, Alma - 2025 - 2.1 Contributo in volume (Capitolo o Saggio))<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1339487\" target=\"_blank\" rel=\"noopener noreferrer\">Harnessing Moringa oleifera Lam&#039;s Isothiocyanates for Targeted H2S Delivery: A Systematic Review of the Literature<\/a> <span class=\"pub-details\">(Ponticelli, M.; Montanaro, R.; Calderone, V.; Vellecco, V.; Piragine, E.; Tzvetkov, N. T.; Milella, L.; Martelli, A.; Brancaleone, V. - 2025 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1338047\" target=\"_blank\" rel=\"noopener noreferrer\">Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study<\/a> <span class=\"pub-details\">(Colletti, A.; Sangiorgio, L.; Martelli, A.; Pellizzato, M.; Cravotto, G. - 2025 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1336827\" target=\"_blank\" rel=\"noopener noreferrer\">Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules<\/a> <span class=\"pub-details\">(Sestito, S.; Cirone, I.; Sagona, S.; Runfola, M.; Raffellini, L.; La Rocca, V.; Citi, V.; Martelli, A.; Daniele, S.; Lai, M.; Calderone, V.; Martini, C.; Manera, C.; Rapposelli, S. - 2025 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1328868\" target=\"_blank\" rel=\"noopener noreferrer\">Functional recovery of islet \u00df cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches<\/a> <span class=\"pub-details\">(Suleiman, M.; Sawatani, T.; Tesi, M.; Yi, X.; Papadopoulou, T.; Rufer, C.; Lytrivi, M.; Bosi, E.; Burdet, F.; Fantuzzi, F.; De Luca, C.; Sebastiani, G.; Saponaro, C.; Pugliese, L. A.; Del Guerra, S.; Pocai, A.; De Simone, P.; Ghinolfi, D.; Boggi, U.; Kessler, C.; Grieco, G. E.; Fignani, D.; Kerr-Conte, J.; Pattou, F.; Nacher, M.; Montanya, E.; Mourad, N.; Buemi, A.; Citi, V.; Martelli, A.; Benedetti, G.; Calderone, V.; Rossi, L.; Paolicchi, A.; Cardarelli, F.; Dotta, F.; Eizirik, D. L.; Ibberson, M.; Marchetti, P.; Cnop, M.; Marselli, L. - 2025 - 1.1 Articolo in rivista)<\/span><\/li><\/ul>","unipi-persone-didattica":"<ul class=\"registri-list\"><li>Farmacologia e farmacoterapia ii a (modulo dell'insegnamento farmacologia e farmacoterapia ii cod. 456ee) per Laurea Magistrale Ciclo Unico 5 anni in Farmacia<\/li><li>Farmacovigilanza e farmacoepidemiologia (cod. 458EE) per Laurea Magistrale Ciclo Unico 5 anni in Farmacia<\/li><li>Farmacognosia e botanica farmaceutica (cod. 455EE) per Laurea Magistrale Ciclo Unico 5 anni in Farmacia<\/li><li>Farmacia clinica territoriale (cod. 531EE) per Laurea Magistrale Ciclo Unico 5 anni in Farmacia<\/li><li>Farmacoterapia i (modulo dell'insegnamento farmacologia generale e farmacoterapia i cod. 457ee) per Laurea Magistrale Ciclo Unico 5 anni in Farmacia<\/li><\/ul>","unipi-persone-codocenze":"","unipi-persone-interessi-ricerca":"","_wpml_word_count":"13","_last_translation_edit_mode":"translation-editor"},"organizzazioni":[3628],"class_list":["post-151117","unipi_persone","type-unipi_persone","status-publish","hentry","organizzazioni-dipartimento-di-farmacia-449999-en"],"email":"alma.martelli@unipi.it","telefono":"050 2219598","content_plain":"Professore Associato &#8211; Dipartimento di Farmacia | Tel.: 050 2219598 &#8211; Email: alma.martelli@unipi.it","photo_url":"https:\/\/www.unipi.it\/fotopersonale\/12967.jpg","ruoli_tags":[{"id":759,"name":"PA","slug":"pa"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Alma Martelli ~ UNIPI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alma Martelli ~ UNIPI\" \/>\n<meta property=\"og:description\" content=\"Professore Associato &#8211; Dipartimento di Farmacia | Tel.: 050 2219598 &#8211; Email: alma.martelli@unipi.it\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/\" \/>\n<meta property=\"og:site_name\" content=\"UNIPI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unipisaofficial\/\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-01T02:45:32+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/\",\"url\":\"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/\",\"name\":\"Alma Martelli ~ UNIPI\",\"isPartOf\":{\"@id\":\"https:\/\/www.unipi.it\/en\/#website\"},\"datePublished\":\"2025-05-12T14:15:17+00:00\",\"dateModified\":\"2026-04-01T02:45:32+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\",\"item\":\"https:\/\/www.unipi.it\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Alma Martelli\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.unipi.it\/en\/#website\",\"url\":\"https:\/\/www.unipi.it\/en\/\",\"name\":\"UNIPI\",\"description\":\"UNIPI\",\"publisher\":{\"@id\":\"https:\/\/www.unipi.it\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.unipi.it\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.unipi.it\/en\/#organization\",\"name\":\"UNIPI\",\"url\":\"https:\/\/www.unipi.it\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.unipi.it\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.unipi.it\/wp-content\/uploads\/Raggruppa-3020.svg\",\"contentUrl\":\"https:\/\/www.unipi.it\/wp-content\/uploads\/Raggruppa-3020.svg\",\"width\":176,\"height\":64,\"caption\":\"UNIPI\"},\"image\":{\"@id\":\"https:\/\/www.unipi.it\/en\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/unipisaofficial\/\",\"https:\/\/www.instagram.com\/unipisa\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alma Martelli ~ UNIPI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/alma-martelli-12967-en\/","og_locale":"en_US","og_type":"article","og_title":"Alma Martelli ~ UNIPI","og_description":"Professore Associato &#8211; 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