Professore Associato – Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia | Tel.: 050 993311 – Email: maria.franzini@unipi.it<\/p>\n","protected":false},"template":"","meta":{"unipi-persone-chiave":"110179","unipi-persone-nome":"Maria","unipi-persone-cognome":"Franzini","unipi-persone-email":"maria.franzini@unipi.it","unipi-persone-cv":"PERSONAL INFORMATION
\r\nPlace and date of birth: Pisa, February 23, 1978.
\r\nInstitutional address: S. Chiara Hospital, Clinical Pathology Laboratory, Building 43, via Roma 67, 56126 Pisa, Italy.
\r\n
\r\nEDUCATION AND TRAINING
\r\n2017: Second-level Master\u2019s Degree in \u201cThrombosis and Hemostasis\u201d with honors, University of Florence.
\r\n2014: Specialization in Clinical Pathology with honors, University of Pisa.
\r\n2007: PhD (Doctor Europaeus label) in \u201cCellular Pathology and Pathophysiology,\u201d University of Siena.
\r\n2003: Degree in Biological Sciences with honors, University of Pisa.
\r\n2001 and 2002: Training periods at Universit\u00e9 H. Poincar\u00e9 - Nancy I (France), \"Thiols and Cellular Functions\" laboratory.
\r\n1997: Scientific High School Diploma, F. Buonarroti High School, Pisa.
\r\n
\r\nPROFESSIONAL EXPERIENCE
\r\n2023: Associate Professor in Clinical Pathology (MEDS-02\/B), University of Pisa with affiliated duties as Senior Biologist at the University Hospital of Pisa.
\r\n2020\u20132023: Fixed-term Researcher (law 240\/2010: art. 24, paragraph 3, letter b) in Clinical Pathology (MEDS-02\/B), University of Pisa with affiliated duties as Senior Biologist at the University Hospital of Pisa.
\r\n2015\u20132020: Fixed-term Researcher (law 240\/2010: art. 24, paragraph 3, letter a) in Clinical Pathology (MEDS-02\/B), University of Pisa with affiliated duties as Senior Biologist at the University Hospital of Pisa.
\r\n2007\u20132011 and 2011\u20132014: Research collaborator at the Scuola Superiore Sant'Anna, studying cardiovascular biomarkers (BNP, NT-proBNP, cardiac troponin, plasma fractions of the enzyme gamma-glutamyltransferase).
\r\n
\r\nMAIN SCIENTIFIC INTERESTS
\r\n- Characterization of circulating fractions of the protein transthyretin and their role in the pathogenesis of cardiac amyloidosis.
\r\n- Evaluation of analytical and clinical characteristics of new immunometric methods for automated determination of cardiac markers (BNP, NT-proBNP, cardiac troponin I and T) and free light chains of antibodies.
\r\n- Characterization of plasma andbiliary fractions of the enzyme gamma-glutamyltransferase (GGT) as indicators of liver damage, liver function post-transplant, and cardiovascular risk factors.
\r\n- Structural and compositional characterization of plasma fractions of GGT.
\r\n- Characterization of cell types capable of releasing the GGT enzyme.
\r\n- Role of membrane-bound GGT activity in modulating the extracellular microenvironment.
\r\n- Role of GGT in the catabolism of nitrosoglutathione.
\r\n- Oxidative stress in neurodegenerative diseases.
\r\n
\r\nCOLLABORATION WITH NATIONAL AND INTERNATIONAL INSTITUTIONS
\r\n- CAMELIA Project (Cardiovascular risks, Metabolic Syndrome, Liver, and Autoimmune Disease): University of Milan; ASL Milan 1; Calabrian Association of Hepatology (Dr. C. Caserta), Reggio Calabria; Istituto Superiore di Sanit\u00e0, Rome.
\r\n- Dr. Alessandro De Grandi, EurAc (Bolzano).
\r\n- Boston Children\u2019s Hospital, Harvard Medical School: Prof. Mark Puder \u2013 collaboration on the project \u201cGGT Characterization in Parenteral Nutrition-Dependent Children\u201d.
\r\n- Framingham Heart Study \u2013 National Heart, Lung, and Blood Institute, Boston University (USA): Prof. Ramachandran Vasan.
\r\n
\r\nCOLLABORATIONS WITH COMPANIES IN THE IVD SECTOR
\r\nIn collaboration with bioM\u00e9rieux Italia S.p.A. (Via di Campigliano 58, Ponte a Ema 50012 Bagno a Ripoli, Florence), the following funded projects were carried out:
\r\n2022\u20132023: \"Improvement of the analytical characteristics of clinical tests for integration on a multiparametric Point of Care system.\"
\r\n2020\u20132021: \"Improvement of analytical characteristics of immunological tests by increasing sensitivity and multiparametric testing capability.\"
\r\n2018\u20132019: \"Improvement of analytical characteristics of immunological tests by controlled orientation of capture-phase antibodies and fluorescence detection.\"
\r\n2016\u20132017: \"Conjugation of fluorochromes for high-sensitivity detection in immunochemical analytical systems.\"","unipi-persone-link-esterno-cv":"","unipi-persone-modalita-ricevimento":"","unipi-persone-luogo-ricevimento":"Laboratorio di Patologia Clinica\nOspedale Santa Chiara, Edificio 43, II piano\nStudio: corridoio sx, prima porta sx\nLaboratorio: corridoio dx, prima porta sx","unipi-persone-ore-ricevimento":"Previo appuntamento da concordare preferibilmente tramite e-mail","unipi-persone-telefono":"050 993311","unipi-persone-sitoweb":"","unipi-persone-cariche":"","unipi-persone-link-orario-lezioni":"https:\/\/unipi.prod.up.cineca.it\/calendarioPubblico\/matricola=012668","unipi-persone-link-registro-lezioni":"https:\/\/unimap.unipi.it\/registri\/registri.php?ri=012668&tmplt=principale.tpl","unipi-persone-settore-scientifico":"Patologia Clinica MEDS-02\/B","unipi-persone-ruolo":"Professore Associato","unipi-persone-arpi":"https:\/\/arpi.unipi.it\/cris\/rp\/rp08384","unipi-persone-pubblicazioni":"