{"id":146073,"date":"2025-05-12T13:57:24","date_gmt":"2025-05-12T13:57:24","guid":{"rendered":"https:\/\/www.unipi.it\/ateneo\/organizzazione\/persone\/gian-carlo-alfredo-giuseppe-demontis-4280-en\/"},"modified":"2026-04-01T04:37:55","modified_gmt":"2026-04-01T02:37:55","slug":"gian-carlo-alfredo-giuseppe-demontis-4280-en","status":"publish","type":"unipi_persone","link":"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/gian-carlo-alfredo-giuseppe-demontis-4280-en\/","title":{"rendered":"Gian Carlo Alfredo Giuseppe Demontis"},"content":{"rendered":"<p>Professore Ordinario &#8211; Dipartimento di Farmacia | Tel.: 050-2219517 &#8211; Email: giancarlo.demontis@unipi.it<\/p>\n","protected":false},"template":"","meta":{"unipi-persone-chiave":"4280","unipi-persone-nome":"Gian Carlo Alfredo Giuseppe","unipi-persone-cognome":"Demontis","unipi-persone-email":"giancarlo.demontis@unipi.it","unipi-persone-cv":"FIRST NAME: GIAN CARLO<br \/>\r\nLAST NAME: DEMONTIS<br \/>\r\nBorn December, 16, 1958 Citizenship: Italian <br \/>\r\nMarital status: Married, 1 daughter <br \/>\r\nEducation and training <br \/>\r\n1980&#8722;1983: Biology courses, University of Pisa.<br \/>\r\n<br \/>\r\n1983: Degree in Biology cum Laude \u2013 <br \/>\r\n1985&#8722;1989: Ph.D. student, Neuroscience \u2013 University of Pisa. <br \/>\r\n1990: Ph.D. in Neuroscience <br \/>\r\n1989&#8722;1990: postdoctoral training at the Department of Pharmacology \u2013 University of Texas Southwestern Medical School at Dallas, TX. <br \/>\r\n1990: short training periods at the department of Neuromorphology, Max&#8722;Planck Institute, Munich and at the Dept. of Pharmacology, University of California at Los Angeles.<br \/>\r\n<br \/>\r\n1991&#8722;1992: postdoctoral training at the Institute for Neurophysiology, National Research Council (CNR), Pisa. <br \/>\r\n<br \/>\r\nEmployment and research experience <br \/>\r\n1992&#8722;2002: Permanent position as Researcher \u2013 Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology \u2013 University of Pisa, Italy.<br \/>\r\n<br \/>\r\n2002&#8722;2006: Associate Professor, Physiology &#8722; Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology \u2013 University of Pisa, Italy. <br \/>\r\n<br \/>\r\n2006&#8722; present: Full Professor, Physiology &#8722; Department of Pharmacy \u2013 University of Pisa, Italy. <br \/>\r\n<br \/>\r\nPast and present research interests:<br \/>\r\n<br \/>\r\n1) cellular and molecular mechanisms involved in the transduction and processing of visual stimuli by rod photoreceptors;<br \/>\r\n<br \/>\r\n2) cellular and molecular mechanisms involved in the generation of oxidative stress in neuronal and endothelial cells;<br \/>\r\n<br \/>\r\n3) functional evaluation of spontaneous mutants and KO mice for their use in translational research.<br \/>\r\n<br \/>\r\n4) functional evaluation of rod-fated cells derived from stem cells or reprogrammed fibroblasts","unipi-persone-link-esterno-cv":"","unipi-persone-modalita-ricevimento":"Lunedi dall 13 alle 14 - Via Bonanno, 6","unipi-persone-luogo-ricevimento":"","unipi-persone-ore-ricevimento":"","unipi-persone-telefono":"050-2219517","unipi-persone-sitoweb":"","unipi-persone-cariche":"","unipi-persone-link-orario-lezioni":"https:\/\/unipi.prod.up.cineca.it\/calendarioPubblico\/matricola=008046","unipi-persone-link-registro-lezioni":"https:\/\/unimap.unipi.it\/registri\/registri.php?ri=008046&tmplt=principale.tpl","unipi-persone-settore-scientifico":"Fisiologia BIOS-06\/A","unipi-persone-ruolo":"Professore Ordinario","unipi-persone-arpi":"https:\/\/arpi.unipi.it\/cris\/rp\/rp12387","unipi-persone-pubblicazioni":"<ul class=\"pubblicazioni-list\"><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1355947\" target=\"_blank\" rel=\"noopener noreferrer\">Identification of a Non-Retinoid Opsin Ligand Through Pharmacophore-Guided Virtual Screening-A Novel Potential Rhodopsin-Stabilizing Compound<\/a> <span class=\"pub-details\">(Di Stefano, Miriana; Ghilardi, Maria; Poles, Clarissa; Piazza, Lisa; Demontis, Gian Carlo; Poli, Giulio; Tuccinardi, Tiziano; Macchia, Marco - 2025 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1312888\" target=\"_blank\" rel=\"noopener noreferrer\">Are Insect-Based Foods Healthy? An Evaluation of the Products Sold in European E-Commerce<\/a> <span class=\"pub-details\">(Copelotti, E.; Fratini, F.; Sforza, G.; Tuccinardi, T.; Demontis, G.; Mancini, S. - 2025 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1238327\" target=\"_blank\" rel=\"noopener noreferrer\">Retinoid Synthesis Regulation by Retinal Cells in Health and Disease<\/a> <span class=\"pub-details\">(Andreazzoli, Massimiliano; Longoni, Biancamaria; Angeloni, Debora; Demontis, GIAN CARLO ALFREDO GIUSEPPE - 2024 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1231369\" target=\"_blank\" rel=\"noopener noreferrer\">An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65<\/a> <span class=\"pub-details\">(Poli, Giulio; Demontis, Gian Carlo; Sodi, Andrea; Saba, Alessandro; Rizzo, Stanislao; Macchia, Marco; Tuccinardi, Tiziano - 2023 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1174726\" target=\"_blank\" rel=\"noopener noreferrer\">Increasing cell culture density during a developmental window prevents fated rod precursors derailment toward hybrid rod-glia cells<\/a> <span class=\"pub-details\">(Barravecchia, Ivana; De Cesari, Chiara; Guadagni, Viviana; Signore, Giovanni; Bertolini, Edoardo; Giannelli, Serena Gea; Scebba, Francesca; Martini, Davide; P\u00e8, Mario Enrico; Broccoli, Vania; Andreazzoli, Massimiliano; Angeloni, Debora; Demontis, Gian Carlo - 2023 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1174725\" target=\"_blank\" rel=\"noopener noreferrer\">Polyunsaturated Lipids in the Light-Exposed and Prooxidant Retinal Environment<\/a> <span class=\"pub-details\">(Longoni, Biancamaria; Demontis, GIAN CARLO ALFREDO GIUSEPPE - 2023 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1200067\" target=\"_blank\" rel=\"noopener noreferrer\">Depleted Calcium Stores and Increased Calcium Entry in Rod Photoreceptors of the Cacna2d4 Mouse Model of Cone-Rod Dystrophy RCD4<\/a> <span class=\"pub-details\">(Demontis, GIAN CARLO ALFREDO GIUSEPPE; Vellani, Vittorio; Mauro, Giovanna - 2022 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1168328\" target=\"_blank\" rel=\"noopener noreferrer\">Depleted Calcium Stores and Increased Calcium Entry in Rod Photoreceptors of the Cacna2d4 Mouse Model of Cone-Rod Dystrophy RCD4<\/a> <span class=\"pub-details\">(Demontis Gian Carlo,Vellani Vittorio,Mauro Giovanna - 2022 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1162653\" target=\"_blank\" rel=\"noopener noreferrer\">Predicting potentially pathogenic effects of hRPE65 missense mutations: a computational strategy based on molecular dynamics simulations<\/a> <span class=\"pub-details\">(Poli, Giulio; Barravecchia, Ivana; Demontis, Gian Carlo; Sodi, Andrea; Saba, Alessandro; Rizzo, Stanislao; Macchia, Marco; Tuccinardi, Tiziano - 2022 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1119485\" target=\"_blank\" rel=\"noopener noreferrer\">HCN1 channels: A versatile tool for signal processing by primary sensory neurons<\/a> <span class=\"pub-details\">(Barravecchia, Ivana; Demontis, GIAN CARLO ALFREDO GIUSEPPE - 2021 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1108292\" target=\"_blank\" rel=\"noopener noreferrer\">Inducible Pluripotent Stem Cells to Model and Treat Inherited Degenerative Diseases of the Outer Retina: 3D-Organoids Limitations and Bioengineering Solutions<\/a> <span class=\"pub-details\">(Andreazzoli, Massimiliano; Barravecchia, Ivana; De Cesari, Chiara; Angeloni, Debora; Demontis, Gian Carlo - 2021 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1104365\" target=\"_blank\" rel=\"noopener noreferrer\">Monoacylglycerol lipase [MAGL] inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold<\/a> <span class=\"pub-details\">(Bononi, G.; Tonarini, G.; Poli, G.; Barravecchia, I.; Caligiuri, I.; Macchia, M.; Rizzolio, F.; Demontis, G. C. A. G.; Minutolo, F.; Granchi, C.; Tuccinardi, T. - 2021 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1066160\" target=\"_blank\" rel=\"noopener noreferrer\">Electrophysiological profile remodeling via selective suppression of voltage-gated currents by CLN1\/PPT1 overexpression in human neuronal-like cells<\/a> <span class=\"pub-details\">(Demontis, GIAN CARLO ALFREDO GIUSEPPE; Pezzini, Francesco; Margari, Elisa; Bianchi, Marzia; Longoni, Biancamaria; Doccini, Stefano; Lalowski Maciej, Maurycy; Santorelli Filippo, Maria; Simonati, Alessandro - 2020 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1063514\" target=\"_blank\" rel=\"noopener noreferrer\">Endocrine adaptations across physical and psychological stressors in long-term space flights<\/a> <span class=\"pub-details\">(Demontis, GIAN CARLO ALFREDO GIUSEPPE; Angeloni, Debora - 2020 - 1.1 Articolo in rivista)<\/span><\/li><li><a href=\"https:\/\/arpi.unipi.it\/handle\/11568\/1016203\" target=\"_blank\" rel=\"noopener noreferrer\">Hydroxyindole-O-methyltransferase [HIOMT] activity in the retina of melatonin-proficient mice<\/a> <span class=\"pub-details\">(Betti, L.; Palego, L.; Demontis, G. C.; Miraglia, F.; Giannaccini, G. - 2019 - 1.1 Articolo in rivista)<\/span><\/li><\/ul>","unipi-persone-didattica":"<ul class=\"registri-list\"><li>Alimentazione e nutrizione umana (cod. 016FE) per Laurea Magistrale in Scienze della nutrizione umana<\/li><\/ul>","unipi-persone-codocenze":"","unipi-persone-interessi-ricerca":"","_wpml_word_count":"18","_last_translation_edit_mode":"translation-editor"},"organizzazioni":[3628],"class_list":["post-146073","unipi_persone","type-unipi_persone","status-publish","hentry","organizzazioni-dipartimento-di-farmacia-449999-en"],"email":"giancarlo.demontis@unipi.it","telefono":"050-2219517","content_plain":"Professore Ordinario &#8211; Dipartimento di Farmacia | Tel.: 050-2219517 &#8211; Email: giancarlo.demontis@unipi.it","photo_url":null,"ruoli_tags":[{"id":748,"name":"PO","slug":"po"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gian Carlo Alfredo Giuseppe Demontis ~ UNIPI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unipi.it\/en\/about-us\/organisation\/people\/gian-carlo-alfredo-giuseppe-demontis-4280-en\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gian Carlo Alfredo Giuseppe Demontis ~ UNIPI\" \/>\n<meta property=\"og:description\" content=\"Professore Ordinario &#8211; 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